Endocrine Abstracts

Context: Hyponatremia is associated with an increased risk of osteoporosis and fractures, and in recent years increasing evidence is accumulating in favor of a likely causal relationship between hyponatremia and bone loss. In rat models, the induction of hyponatremia enhances osteoclast activation and bone catabolism. In humans, the correction of hyponatremia by tolvaptan or SGLT2-inhibitors has a favorable effect on bone turnover markers, possibly due to an interplay both wit...

X-linked hypophosphatemia (XLH) is a rare genetic disease due to inactivation of the PHEX gene, which results in enhanced secretion of the phosphaturic hormone fibroblast growth factor 23 (FGF23); the latter induces renal phosphate wasting and hypophosphatemia. Skeletal and dental anomalies and recently described increase in cardiovascular risk are typical clinical findings. We retrospectively evaluated 58 adult patients with XLH from 9 Italian tertiary centres [34 females, 24...